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1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34822784
2.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33891333
3.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33351971
4.
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
Cancer Sci
; 103(3): 522-7, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22181674
5.
An evaluation of reproductive and developmental toxicity of sitaxentan (thelin) in rats.
Birth Defects Res B Dev Reprod Toxicol
; 95(5): 327-36, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22890981
6.
Tissue distribution of anidulafungin in neonatal rats.
Birth Defects Res B Dev Reprod Toxicol
; 95(1): 89-94, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22311649
7.
Evaluation of sitaxentan (Thelin®) toxicity in juvenile rats and regulatory interactions during the development of a European Medicines Agency pediatric investigation plan.
Regul Toxicol Pharmacol
; 64(1): 43-50, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22683288
8.
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension.
Regul Toxicol Pharmacol
; 64(1): 95-103, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22683289
9.
Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan.
Regul Toxicol Pharmacol
; 63(1): 29-39, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22343256
10.
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Alzheimers Dement (N Y)
; 8(1): e12273, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35229025
11.
Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges.
Birth Defects Res B Dev Reprod Toxicol
; 92(4): 333-44, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21594975
12.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Drugs R D
; 21(3): 295-304, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34164794
13.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33883008
14.
Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
Mol Cancer Ther
; 8(2): 324-32, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19174555
15.
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
J Med Chem
; 52(2): 379-88, 2009 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-19143567
16.
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
J Med Chem
; 51(16): 4986-99, 2008 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18656911
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